| 摘要 |
The present invention relates to recombinant oncolytic viruses that comprise in their viral genome the genetic information for a si-RNA, sh-RNA, antisense-DNA, antisense-RNA, sc- AB or sd-AB for inhibiting the gene AVEN or its expression product in a target or host cell, and pharmaceutical compositions thereof. The present invention further relates to the use of said oncolytic viruses as gene delivery tool and/or for tumor detection. The present invention further relates to the medical uses of said oncolytic viruses, in particular in oncolytic virotherapy and for the diagnosis, prevention and/or treatment of diseases, such as cancer. |
