COMPOUND HAVING SOMATOSTATIN RECEPTOR AGONISTIC ACTIVITY AND PHARMACEUTICAL USE THEREOF

摘要

The present invention provides a somatostatin receptor subtype 2 agonist. A disclosed compound represented by the general formula (I):;;wherein all symbols have the same definitions as described in the specification;

a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug of the foregoing is a low-molecular compound having strong somatostatin receptor subtype 2 agonistic activity, and thus can be administered in a simple manner, has high stability and has low toxicity. Therefore, the present compound is useful for prophylaxis and/or therapy of somatostatin-related diseases such as acromegaly and gastrointestinal obstruction.

主权项

1. A compound represented by the general formula (I): wherein R1 represents (1) a halogen atom, (2) a cyano group, (3) a C1-4 alkyl, (4) a C1-4 alkoxy or (5) a C3-8 cycloalkyl, wherein the C1-4 alkyl, the C1-4 alkoxy and the C3-8 cycloalkyl may be respectively and independently substituted with 1 to 3 halogen atoms and/or cyano groups; p represents an integer of 0 to 2; when p is 2, a plurality of R1 may be the same or different; R2 and R3 respectively and independently represent a hydrogen atom or a C1-4 alkyl; R4 represents a hydrogen atom; or R2 and R4 together with an atom to which the R2 and R4 are attached may form a 5- to 8-membered nitrogen-containing saturated heterocycle; L represents (1) a bond, (2) —CRA═CRB→ or (3) —C(═O)—NRD→ (wherein in each group, the arrow indicates the site of binding to the pyridine ring); RA, RB and RD respectively and independently represent a hydrogen atom or a C1-4 alkyl; X1 and X2 respectively and independently represent a halogen atom; a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug of the foregoing.