发明名称 |
Indoles useful for treating cellular proliferation diseases such as cancer |
摘要 |
Disclosed are compounds of general formula (I), wherein the substituents are as defined herein. Further disclosed is a pharmaceutical composition comprising N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, for inhibiting the proliferation of and/or inducing apoptosis in cancer cells. |
申请公布号 |
NZ603454(A) |
申请公布日期 |
2014.06.27 |
申请号 |
NZ20110603454 |
申请日期 |
2011.05.05 |
申请人 |
GLAXOSMITHKLINE LLC |
发明人 |
BRACKLEY JAMES;BURGESS JOELLE LORRAINE;GRANT SETH;JOHNSON NEIL;KNIGHT STEVEN D.;LAFRANCE LOUIS;MILLER WILLIAM H.;NEWLANDER KENNETH;ROMERIL STUART;ROUSE MEAGAN B.;TIAN XINRONG;VERMA SHARAD KUMAR |
分类号 |
C07D209/08;A61K31/404;A61K31/4412;A61K31/4439;C07D209/42;C07D213/64;C07D213/74;C07D295/04 |
主分类号 |
C07D209/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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