| 摘要 |
The present invention provides novel methods for determining whether a compound influences a phase in the life cycle of a virus comprising providin g a cell with said compound and with at least a fragment of said virus sufficient for performing said phase and determing whether said phase is influenced in said cell, said cell comprising a nucleic acid encoding an adenovirus early protein or a functional part, derivative and/or analogue of said adenovirus early protein. In another aspect the invention provides the use of a cell, said cell comprising nucleic acid encoding an adenovirus earl y protein, for screening a library of compounds for the presence of a compound capable of influencing a phase in the life cycle of a virus capable of entering said cell. In yet another aspect, the invention provides novel methods for identifying a compound with antiviral activity comprising providing a cell with at least a fragment of a virus, said fragment capable of performing a step in the life cycle of said virus, providing said cell with a compound and determining whether said compound is capable of influencing sai d step in the life cycle of said virus, wherein said cell comprises a nucleic acid encoding an adenovirus early protein or a functional part, derivative and/or analogue of said adenovirus early protein. |
