MACROMOLECULAR CLUSTERS OF CARDIAC STEM CELLS AND METHODS FOR MAKING AND USING THEM

摘要

In alternative embodiments, provided are macrocellular structures or artificially configured plurality of cells, the so-called “cardioclusters” as provided herein, comprising: a core region or cluster: comprising a plurality of first cardiac stem cells or cardiac progenitor cells; and a second region or a peripheral region positioned at least partially surrounding the outer surface of the core region or cluster, or at least partially around the core region or cluster, comprising a plurality of second cardiac stem cells; and methods for making and using them. In alternative embodiments, the second cardiac progenitor cells are cardiac progenitor cells or cardiac stem cells, mesenchymal stem cells or mesenchymal progenitor cells, or endothelial progenitor cells or endothelial stem cells.

主权项

1. A macrocellular structure, a cardiocluster of cells, or an artificially configured plurality of cells, comprising:
a core region or cluster: comprising a plurality of first cardiac stem cells or cardiac progenitor cells; and a second region or a peripheral region positioned: at least partially surrounding the outer surface of the core region or cluster, or at least partially around the core region or cluster, comprising a plurality of second cardiac stem cells, wherein the first cardiac stem cells and the second cardiac stem cells are different, and the second cardiac progenitor cells are selected from the group consisting of: a plurality of cardiac progenitor cells or cardiac stem cells, a plurality of mesenchymal stem cells or mesenchymal progenitor cells, a plurality of endothelial progenitor cells or endothelial stem cells, and a combination thereof.