发明名称 |
DETECTION, MONITORING AND TREATMENT OF CANCER |
摘要 |
There are disclosed aptamer ligands to MUCl, preferably comprising a sequenc e selected from: 1 CGAATGGGCCCGTCCTCGCTGTAAG 2 GCAACAGGGTATCCAAAGGATCAAA 3 GTTCGACAGGAGGCTCACAACAGGC 4 TGTTGGTCAGGCGGCGGCTCTACAT 5 CTCTGTTCTTATTTGCGAGTTXXXX 6 XCTCTGTTCTTATTTGCGAGTTXXX 7 XXCTCTGTTCTTATTTGCGAGTTXX 8 XXXCTCTGTTCTTATTTGCGAGTTX 9 XXXXCTCTGTTCTTATTTGCGAGTT 10 CTCTGTTCTTATTTGCGAGTT 11 CCCTCTGTTCTTATTTGCGAGTTCA 12 CTCTGTTCTTATTTGCGAGTTGGTG 13 CCCTCTGTTCTTATTTGCGAGTTCA 14 TAAGAACAGGGCGTCGTGTTACGAG 15 GTGGCTTACTGCGAGGACGGGCCCA 16 GCAGTTGATCCTTTGGATACCCTGG 17 AACCCTATCCACTTTTCGGCTCGGG 18 CGATTTAGTCTCTGTCTCTAGGGGT 19 CGACAGGAGGCTCACAACAGGCAAC 20 AGAACGAAGCGTTCGACAGGAGGCT 21 AGAAACACTTGGTATATCGCAGATA 22 GGGAGACAAGAATAAACACTCAACG and compounds comprising these aptamers and sequences. There are also disclosed compounds having the structure formula (I) and (II). There are also disclosed methods of treatment, diagnosis, detection and imaging using these compounds, their use in such methods, and their use in the preparation of medicaments and product s for such methods.
|
申请公布号 |
CA2518783(A1) |
申请公布日期 |
2004.09.23 |
申请号 |
CA20042518783 |
申请日期 |
2004.03.10 |
申请人 |
THE OPEN UNIVERSITY |
发明人 |
FERREIRA, CATIA SOFIA MATOS;BORBAS, KATALIN ESZTER;MISSAILIDIS, SOTIRIS;BRUCE, JAMES IRONSIDE |
分类号 |
A61K49/00;C07H21/00;G01N33/574;(IPC1-7):G01N33/574;A61K31/70 |
主分类号 |
A61K49/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|