METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY

摘要

Disclosed are compounds and pharmaceutically acceptable compositions thereof which modulate the interaction between nerve growth factor and precursors thereof and neurotrophm receptors and treat disease conditions mediated therefrom such as pam, inflammatory disorders and neurological disorders Also disclosed are methods of using the compounds and compositions of the invention, including methods of administration The compounds have the following structural formula wherein m and n are independently 0 or 1 , x and y are independently 0 or 1, provided that n and y are not 0 at the same time, and the substituents R¹-R⁵, R¹⁰ and R¹¹ are further defined