Tissue-derived tissuegenic implants, and methods of fabricating and using same

摘要

The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.

主权项

1. A tissue-derived implant for implantation in a recipient allogeneic to a donor of the implant, the implant as a whole comprising:
(a) at least one tissue-derived growth conductive matrix of the donor from which measurable immunologically reactive hematopoietic cells have been removed; and (b) at least one viable population of nonexpanded tissuegenic cells endogenous to the growth conductive matrix of the donor that remains adherent to and resident in an endogenous milieu of the growth conductive matrix; with the proviso that, before implantation, the implant is not reconstituted with cells exogenous to the tissue-derived growth conductive matrix of the donor.