发明名称 |
ENGINEERED PRIMATE L-METHIONINASE FOR THERAPEUTIC PURPOSES |
摘要 |
Methods and compositions relating to the engineering of an improved protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids. |
申请公布号 |
EP3039139(A2) |
申请公布日期 |
2016.07.06 |
申请号 |
EP20140841106 |
申请日期 |
2014.08.29 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GEORGIOU, GEORGE;STONE, EVERETT;LU, WEI-CHENG |
分类号 |
C12N15/60;A61K38/51;A61P35/00 |
主分类号 |
C12N15/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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