Anti-wrinkle cosmetic composition

摘要

Cosmetic use of 4-amino piperidine derivatives (I) and their salts, optical isomers and solvates, as agents to combat wrinkles, e.g. expression wrinkles, skin relaxation and/or loosen lines. Cosmetic use of 4-amino piperidine derivatives of formula (I) and their salts, optical isomers and solvates, as an agent to combat wrinkles, e.g. expression wrinkles, skin relaxation and/or loosen lines. Alk1, Alk2saturated 1-10C, unsaturated 2-10C or branched 3-10C alkylene, preferably saturated 1-4C or branched 3-4C alkylene; Ar1phenyl (optionally substituted by -F, -CF3, -R1, -OR1 or -NR1R2), preferably phenyl group; Ar2phenyl (optionally substituted by -F, -CF3 or -NR1R2), preferably phenyl group; R : saturated 1-10C or branched 3-10C alkyl (optionally substituted by -Ar1, -OR1 or -NR1R2) or H, preferably H; and R1, R2saturated 1-7C, unsaturated 2-7C or branched 3-7C alkyl. Independent claims are included for: the cosmetic treatment process of skin, such as wrinkled skin, particularly facial and/or front skin, comprising topical application of a composition comprising (I) in a medium, on the skin; #a composition comprising (I) in a medium; #4-amino piperidine derivatives (I) in which Alk1 is saturated 1-10C, unsaturated 2-10C alkylene or branched 3-10C alkylene and Alk2 is branched 3-10C alkylene; #preparation of (I) comprising alkylation of 1,1-dimethyl-1,1-dimethyl-4-oxopiperidinium iodide of formula (III) with an alkylamine of formula (Ar1-Alk1-NH2) to obtain a piperidone compound of formula (IV), reducing and alkylating (IV) with an alkylamine of formula (Ar2-Alk2-NH2) to obtain (Ix) (representation of (I)), when R is hydrogen, or comprising acylation of (Ix) with an acid chloride of formula (RCOCl) in the presence of an organic base to form an intermediate amide compound followed by reduction of the amide in the presence of lithium aluminum hydride to obtain (Iy) (representative of (I), where R5 is not defined), when R is different from a hydrogen. [Image] [Image].