发明名称 |
THERAPEUTIC EFFECTS OF BRYOSTATINS ON ISCHEMIA/STROKE-INDUCED MEMORY IMPAIRMENT AND BRAIN INJURY |
摘要 |
<p>The invention provides for the use of protein kinase activators or boosters of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) or other neurotrophic factors to treat stroke. Specifically, the present invention provides methods of treating stroke comprising the steps of identifying a subject having suffered a stroke and administering to said subject an amount of a pharmaceutical composition comprising a protein kinase C (PKC) activator or 4-methylcatechol acetic acid (MCBA) and a pharmaceutically acceptable carrier effective to treat at least one symptom of stroke.</p> |
申请公布号 |
EP2121001(A2) |
申请公布日期 |
2009.11.25 |
申请号 |
EP20080725396 |
申请日期 |
2008.02.11 |
申请人 |
BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE |
发明人 |
SUN, MIAO-KUN;ALKON, DANIEL, L. |
分类号 |
A61K38/18;A61K31/00;A61K31/05;A61K31/335;A61K31/35;A61K31/365;A61K31/395;A61K31/4015;A61K45/00;A61P25/00;A61P25/28 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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