IMAGING REDUCTIONS IN CEREBROVASCULAR REACTIVITY

摘要

An algorithm including program code for analyzing a specific portion of the vasoactive response to the vasoactive stimulus corresponding to a to sub-range of increments and/or decrements of stimuli within the full range of the vasoactive stimulus, the sub-range characterized in that is more sensitive to identifying reductions in vascular reactivity in the ROI.

主权项

1. A system for detecting an abnormality in a subject's cerebrovascular response to a vasoactive stimulus in at least one region of interest (ROI) of the subject's brain, comprising:
(A) a system for generating the vasoactive stimulus (SVS); (B) an imaging system (IS) characterized in that it provides sufficient spatial resolution for analyzing a vasoactive response to a series of increments and/or decrements in the vasoactive stimulus, the vasoactive response preferably constituting a surrogate measure of blood flow in the at least one ROI; (C) a computer for implementing an algorithm for analyzing the vasoactive response to a series of increments and/or decrements in a vasoactive stimulus, the algorithm including program code for computing at least one value representing a quantitative measure of cerebrovascular reactivity for the ROI, wherein the at least one value is obtained for a specific portion of the vasoactive response in the ROI, the specific portion of the response corresponding to a to sub-range of increments and/or decrements in the vasoactive stimulus within the full range of the vasoactive stimulus, the sub-range characterized in that it is sensitive to quantifying a reduction in cerebrovascular reactivity.