| 发明名称 |
MOUSE MODEL FOR ENGRAFTMENT POTENTIAL |
| 摘要 |
Disclosed herein is the generation of a permissive murine strain (NSGW) that exhibits enhanced levels of human chimerism without pre-conditioning. |
| 申请公布号 |
US2016219843(A1) |
申请公布日期 |
2016.08.04 |
| 申请号 |
US201415026856 |
申请日期 |
2014.10.02 |
| 申请人 |
CELLULAR DYNAMICS INTERNATIONAL, INC. |
发明人 |
THOMSON James;MCINTOSH Brian;SLUKVIN Igor |
| 分类号 |
A01K67/027 |
主分类号 |
A01K67/027 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A mouse whose genome comprises: (i) a homozygous non-obese diabetic (NOD) polymorphism of a Sirpa gene; (ii) a homozygous scid mutation of a Prkdc gene; (iii) a homozygous disruption of a Il2rγ gene; and (iv) a homozygous W41 mutation of a Kit gene. |
| 地址 |
Madison WI US |
