| 发明名称 |
NOVEL BACULOVIRUS DISPLAY VECTORS AND USES THEREOF |
| 摘要 |
A recombinant baculovirus displaying on its envelop a fusion protein is disclosed. The fusion protein comprises a heterologous antigen, and a C-terminal region of baculovirus envelope GP64 protein, which has at least 100 amino acid residues in length and lacks a B12D5 binding epitope located within the central basic region of the GP64 protein. The genome of the recombinant baculovirus comprises a transgene encoding a fusion protein that comprises a signal peptide, the heterologous antigen, and the C-terminal region of the baculovirus envelope GP64 protein, in which the antigen is located between the signal peptide and the C-terminal region of the GP64 protein. Methods for eliciting an antigen-specific immunogenic response in a subject in need thereof are also disclosed. |
| 申请公布号 |
US2016331826(A1) |
申请公布日期 |
2016.11.17 |
| 申请号 |
US201615153851 |
申请日期 |
2016.05.13 |
| 申请人 |
Reber Genetics Co., Ltd. |
发明人 |
CHANG Chia-Jung;LIAO Yan-Chiou;CHOU Wei-I;CHANG Hsiu-Kang |
| 分类号 |
A61K39/12;C12N7/00 |
主分类号 |
A61K39/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A vector comprising a transgene encoding a fusion protein, the fusion protein comprising:
(a) a signal peptide located at the N-terminus of the fusion protein; (b) a heterologous antigen; and (c) a C-terminal region of baculovirus envelope GP64 protein, having at least 100 amino acid residues in length and lacking a B12D5 binding epitope located within the central basic region of the GP64 protein; wherein the heterologous antigen is located between the signal peptide and the C-terminal region of the GP64 protein. |
| 地址 |
Taipei City TW |
