<p>A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.</p>
申请公布号
EP1516628(A1)
申请公布日期
2005.03.23
申请号
EP20040022777
申请日期
1996.07.23
申请人
GENENTECH, INC.
发明人
ANDYA, JAMES;CLELAND, JEFFREY L.;HSU, CHUNG C.;LAM, XANTHE M.;OVERCASHIER, DAVID E.;SHIRE, STEVEN J.;YANG, JANET YU-FENG;WU, SYLVIA SAU-YAN