SUBSTANTIALLY SURFACTANT-FREE, SUBMICRON DISPERSIONS OF HYDROPHOBIC AGENTS CONTAINING HIGH LEVELS OF WATER MISCIBLE SOLVENT

摘要

A composition is provided to apply to the skin, hair, or external mucosa of a human or animal, and a method for using the composition. The composition includes for example a composition for application to skin, hair or external mucosa comprising: a) dispersed submicron particles of hydrophobic agent(s) having average particle size from 100 nm to 999 nm; b) an aqueous-solvent fluid; and c) rheological modifying agent(s); wherein the aqueous-solvent fluid is 10% to 95% wt. of one or more water miscible solvent(s), 4.99% to 89.99% wt. water, and 0.01% to 10% wt. of the rheological modifying agent(s); and wherein the hydrophobic agents comprise 0.01 to 70% wt. of the skin, hair or mucosal composition; and wherein the composition is substantially surfactant-free.

主权项

1. A composition for application to skin, hair or external mucosa comprising:
an aqueous-solvent fluid and submicron particles of hydrophobic agent(s) dispersed and suspended in the aqueous-solvent fluid; wherein the aqueous-solvent fluid comprises:
20% to 95% wt. of at least one water miscible solvent(s), andwater; wherein the water miscible solvent(s) comprises at least one mono-, di- or poly-hydroxy compound represented by formula A: wherein X, Y and Z are independently —H or —OH; W is independently —H or —CH3; m is 0 or 1; and n is an integer from 0 to 6; wherein the composition is substantially surfactant-free, wherein the amount of surfactant, if present, is not sufficient to materially lower the surface tension of the aqueous-solvent fluid; and wherein the dispersed submicron particles are stable.