Pharmaceuticals for Oral Delivery

摘要

The present invention provides pharmaceutical compositions suitable for oral delivery and methods of treating subjects in need thereof. The pharmaceutical compositions of the present invention enhance bioavailability of at least one compound classified as BCS Class II, BCS Class III or BCS Class IV.

主权项

1. A solid oral dosage form comprising:
a mixture comprising:
a therapeutically effective amount of an aminoglycoside;an absorption enhancer; andfrom 100 mg to 500 mg of coated citric acid particles, wherein the citric acid particles are coated with a water soluble coat that separates the citric acid from the aminoglycoside, wherein, if the dosage form was added to ten milliliters of 0.1 M aqueous sodium bicarbonate solution, the pH of the solution would be acidified to a pH no higher than 5.5; an enteric coating; and a water soluble barrier positioned between the mixture and the enteric coating, thereby separating the mixture from the enteric coating.