摘要 |
This invention relates to the field of anticancer therapy, and to the identification of immunogenic peptides derived from the human telomerase reverse transcriptase (hTERT). The present invention relates to polynucleotides encoding hTERT epitopes restricted to MHC class I molecule, analogues thereof and polyepitopes containing such epitopes and/or analogues. Are also included in the present invention, vector and cell comprising such polynucleotides. The present invention also concerns composition comprising hTERT polypeptides, corresponding polynucleotides, vectors and cells, for use in the treatment and/or prevention of cancer. |
申请人 |
INSTITUT PASTEUR;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);LANGLADE-DEMOYEN, PIERRE;GARCIA PONS, FRANCISCO;ADOTEVI, OLIVIER;CARDINAUD, SYLVAIN;NEUVEUT, CHRISTINE |
发明人 |
LANGLADE-DEMOYEN, PIERRE;GARCIA PONS, FRANCISCO;ADOTEVI, OLIVIER;CARDINAUD, SYLVAIN;NEUVEUT, CHRISTINE |