METHOD FOR PRODUCTION OF PROANTHOCYANIDIN POLYMER COMPOSITION

摘要

FIELD: pharmaceutics.SUBSTANCE: invention relates to a method for production of Crofelemer comprising defined steps. Step A comprises isolating partially purified Crofelemer by stirring a mixture of crude plant latex or freeze-dried powder of plant latex and water at a temperature in range of 35 to 45 °C. Stage B comprises purifying partially purified Crofelemer using column chromatography.EFFECT: method described above enables to obtain Crofelemer, which is a more efficient, cheap, environmentally safe and provides a product with low content of impurities.44 cl, 4 tbl, 14 ex