| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to pyrrolopyrimidine compounds of formula (I), which possess properties of an inhibitor of at least one kinase, selected from JAK1, JAK2, JAK3 and TYK2, or their pharmaceutically acceptable salt. In formula (I) compound:,Ris selected from hydrogen, C-Calkyl, C-Ccycloalkyl; Ris selected from aryl, heterocycle, heteroaryl, -C(O)NRR, -S(O)Rand -S(O)NRR, and each of the said alkyl, aryl, cycloalkyl, heterocycle, heteroaryl in Rand Ris possibly substituted with one or more groups, selected from a possibly substituted C-Calkyl, possibly substituted aryl, possibly substituted C-Calkinyl, C-Ccycloalkyl, -C(O)OR, -CN, -C(O)NRR, halogen, possibly substituted heterocycle, possibly substituted heteroaryl, NRR, -NRC(O)R, -NRS(O)R, -NO, -OR, -S(O)Rand -S(O)NRR; m equals 1 and n equals 2; in each case R, R, R, R, Rand Reach is independently selected from hydrogen, possibly substituted C-Calkyl, possibly substituted C-Calkinyl, possibly substituted C-Ccycloalkyl, possibly substituted aryl, possibly substituted heteroaryl and possibly substituted heterocycle; or Rand Rwith a nitrogen atom, which they are bound to, form a heterocyclic ring, which is possibly substituted with one or more groups, selected from halogen, C-Calkyl, hydroxyl and C-Calkoxy, where the heterocyclic ring also possibly contains one or two additional heteroatoms, selected from N, O and S; where each possibly substituted the said group can be non-substituted or independently substituted with one or more substituents, independently selected from C-Calkyl, C-Ccycloalkyl, aryl, heterocycle, C-Chaloalkyl, -OC-Calkyl, -C-Calkyl-O-C-Calkyl, halogen, -OH, -NH, -N(C-Calkyl)(C-Calkyl), -CN, and -NO, in which each aryl, heterocycle are possibly substituted with one or more groups, selected from halogen and C-Calkyl.EFFECT: obtaining a medication for the treatment of an inflammatory disease or cancer, sensitive to the inhibition of at least one kinase of the said kinases, is achieved.24 cl, 1 tbl, 3 ex |
