| 摘要 |
Disclosed is an antibody polypeptide comprising a first variable domain, wherein the antibody polypeptide specifically binds an epitope of human CD40, wherein the antibody polypeptide competes with the binding of domain antibody (dAb) BMS3h-56-269 (SEQ ID NO: 417) to CD40, wherein CD40 comprises the amino acid sequence of SEQ ID NO: 1, and wherein the epitope comprises at least one CD40 amino acid residue selected from the group consisting of Trp109, Leu121, His122, Ser124, Ser156, Ala157, Phe158, Glu159, and His162, wherein the antibody polypeptide is a domain antibody, and wherein the binding of the antibody polypeptide to CD40 antagonizes CD40 activity, wherein the sequence is as defined in the specification. |
