METHOD OF PREPARATION AND USE OF PHARMACOLOGICALLY ACTIVE N-CARBAMOYLMETHYL-4(R)-PHENYL-2-PYRROLIDINONE
摘要
<p>The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2 -pyrrolidinone (R- Carphedon) of pharmacological value. The method of its pr eparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethy l bromoacetate in the presence of a strong base and the treatment of interme diate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.</SDOA B></p>