| 发明名称 |
Solid Forms of Ivacaftor and Processes for the Preparation Thereof |
| 摘要 |
Provided herein is a polymorphic form of Ivacaftor, namely APO-I, as well as processes for the preparation and pharmaceutical compositions of the same. Also, provided is a new solvate of Ivacaftor, processes for its preparation and use in the preparation of pure Ivacaftor. |
| 申请公布号 |
US2016280654(A1) |
申请公布日期 |
2016.09.29 |
| 申请号 |
US201415036137 |
申请日期 |
2014.11.13 |
| 申请人 |
APOTEX INC. |
发明人 |
Akbarali Padiyath Mohammed;Venkata Ramana Kintali;Shreenivasa Murthy Heggadde Nanjunda Bhatta;Suresh Kumar Sankaran;Vijaya Bhaskar Ekkaluru;Sunil Kumar Nechipadappu;Manjunath Karad |
| 分类号 |
C07D215/56 |
主分类号 |
C07D215/56 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polymorphic form APO-I of Ivacaftor having a powder x-ray diffractogram comprising peaks, in terms of 2-theta degrees, at: 4.3±0.2, 4.8±0.2, 9.5±0.2, 13.0±0.2, 20.0±0.2 and 28.8±0.2. |
| 地址 |
Toronto CA |
