METHOD FOR DETECTION OF DNA DAMAGE USING Frag1 GENE OR GENE PRODUCT THEREOF AS MARKER

摘要

Disclosed are a novel molecular marker which enables to detect a DNA damage or unscheduled replication of DNA which may directly cause a genetic change or the like, with high sensitivity, and the like. A method for detecting a DNA damage by using, as a marker, a Frag1 gene, a gene product of the gene or a phosphorylated product of the gene product or a cellular response associated with the gene or product in a sample; a method for screening for an exogenous stimulation involving any one of various carcinogenic substances including various DNA replication inhibitors, carcinogens and potential carcinogens or for an anti-cancerous agent; a method for testing or diagnosing a disease associated with the expression or activity of Frag1; a kit for use in these methods; and the like.