Biomarkers for Determining an Allograft Tolerant Phenotype

摘要

Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression level of one or more gene in a sample from the subject, e.g., a blood sample, is assayed to obtain a gene expression result, where the gene expression result includes a result for a biomarker of graft tolerance. The obtained gene expression result is then employed to determine whether the subject has a graft tolerant phenotype. Also provided are compositions, systems and kits that find use in practicing the subject methods. The methods and compositions find use in a variety of applications, including the determination of an immunosuppressive therapy regimen.

主权项

1. A method of determining whether a subject who has received an allograft has a graft tolerant phenotype, said method comprising:
(a) evaluating the level of expression of one or more gene in a sample from said subject to obtain a gene expression result, wherein said one or more genes is selected from Table 1A and/or 1B; and (b) determining whether said subject has a graft tolerant phenotype based on said gene expression result.