发明名称 |
YKL-40 MONOCLONAL ANTIBODIES |
摘要 |
<p>The present invention relates to monoclonal anti-human YKL- antibodies which are capable to modulate biological processes in which YKL-40 plays a prominat role, e.g. inhibit the growth and/or inducing apoptosis of cells, in particular cancer cells. The invention also relates to pharmaceutical compositions comprising said antibodies and uses said antibodies and/or pharmaceutical compositions for treatment of a disease wherein inhibition of cell growth, cell differentiation, remodelling of extracellular matrix, metastasis and/or induction of cell death due to apoptosis is a prerequisite for successful curing. An antibody of the invention is capable of inhibiting biological function of YKL-40 in the above mentioned processes by binding to a specific epitope on YKL-40.</p> |
申请公布号 |
WO2006089549(A1) |
申请公布日期 |
2006.08.31 |
申请号 |
WO2006DK00093 |
申请日期 |
2006.02.16 |
申请人 |
BIO-Y A/S;BONNICHSEN, RICHARD;PRICE, PAUL, A. |
发明人 |
BONNICHSEN, RICHARD;PRICE, PAUL, A. |
分类号 |
C07K16/18;A61K38/08;A61K38/10;A61K39/00;A61K39/395;A61P1/16;A61P29/00;A61P35/00;A61P35/04;A61P37/00;C07K14/47 |
主分类号 |
C07K16/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|