SYSTEM AND METHOD FOR NEUROMORPHIC CONTROLLED ADAPTIVE PACING OF RESPIRATORY MUSCLES AND NERVES

摘要

Adaptive systems and methods for automatically determining and continuously updating stimulation parameters for adjusting ventilation to accommodate a patient's specific physiology, metabolic needs, and muscle state are disclosed herein. Having a closed loop implementation, the system may comprise a controller including a neuromorphic controlled adaptive feed-forward Pattern Generator/Pattern Shaper (PG/PS) assembly, which controls respiratory muscle movement using electrical stimulation. This PG/PS assembly comprises a biomimetic design where the pattern generator includes a neural network mimicking the simplified connectivity pattern of respiratory related neurons in the brain stem to produce a rhythmic breathing pattern frequency and the pattern shaper includes a neural network mimicking the simplified connectivity pattern of neurons to produce a stimulus control signal. This biomimetic design for the controller automatically customizes and continually updates stimulation parameters to achieve a desired breathing pattern and, thereby, slow the development of muscle fatigue.

主权项

1. A system for adaptive pacing of respiratory muscles and nerves, comprising:
at least one electrode implanted in at least one tissue associated with controlling a breathing pattern frequency of a user; a first feedback section having at least one sensor for detecting at least one physiological parameter of the user; and a controller coupled to the at least one electrode and the first feedback section, wherein the controller comprises a feed-forward section for generating a stimulus control signal for adjusting the breathing pattern frequency using a first difference between the detected at least one physiological parameter and at least one desired physiological parameter, wherein the at least one electrode controls the movement of the at least one tissue in response to receipt of the stimulus control signal sent by the controller; wherein the feed-forward section comprises a pattern generator coupled between a first comparator and a pattern shaper, wherein the first comparator generates the first difference; wherein the pattern generator comprises a biomimetic design having a first neural network mimicking a simplified connectivity pattern of respiratory realted neurons of a brain stem to produce the breathing pattern frequency; wherein the pattern shaper comprises a biomimetic design having a second neural network mimicking a simplified connectivity pattern of phrenic motorneurons that determines based upon the breathing pattern frequency at least one amplitude of at least one stimulus pulse and at least one frequency of the at least one stimulus pulse, the pattern shaper produces the stimulus control signal including the at least one amplitude and the at least one frequency.