| 发明名称 |
Methods of Manipulating Phagocytosis Mediated by CD47 |
| 摘要 |
Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc. |
| 申请公布号 |
US2016176976(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
US201615054930 |
申请日期 |
2016.02.26 |
| 申请人 |
The Board of Trustees of the Leland Stanford Junior University |
发明人 |
Jaiswal Siddhartha;Weissman Irving L.;Majeti Ravindra;Chao Mark P. |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a human subject for ovarian cancer, the method comprising:
administering to a human subject in need thereof an antibody that disrupts the binding of CD47 with SIRPα, at a dose that achieves a depletion in ovarian cancer cells by increasing phagocytosis of cancer cells. |
| 地址 |
Stanford CA US |
