摘要 |
<p>The present invention provides methods for identifying cognate binding pairs from two libraries of biomolecules (e.g., polypeptides). The methods typically involve displaying a first library of candidate biomolecules (e.g., receptors or epitopes) on a first replicable genetic package (e.g., a cell surface display platform) and displaying a second library of candidate biomolecules (e.g., ligands) on a second replicable genetic package (e.g., a phage display platform), contacting the first library with the second library, and then selecting members of the first library to which a member of the second library is bound. Also provided in the invention are compositions and kits for carrying out the methods of the invention.</p> |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE;BOWLEY, DIANA, R.;JONES, TERESA, M.;BURTON, DENNIS, R.;LERNER, RICHARD, A. |
发明人 |
BOWLEY, DIANA, R.;JONES, TERESA, M.;BURTON, DENNIS, R.;LERNER, RICHARD, A. |