METHOD FOR THE RATIONAL MUTAGENESIS OF A/BETA T CELL RECEPTORS AND CORRESPONDINGLY MUTATED MDM2 PROTEIN-SPECIFIC A/BETA T-CELL RECEPTORS

摘要

The invention relates to the rational mutagenesis of polypeptides ofα/βT-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specificα/βT-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.