| 摘要 |
The present invention discloses microRNAs (miR) involved in the regulation of the lipid and glucose metabolism. Several conserved miR molecules were found as direct targets of the glucocorticoid hormone/glucocorticoid receptor signaling axis. Hence, the present invention pertains to inhibitors of these miRs—such as antimiRs and blockmiRs—as well as isolated miR molecules or miR expression constructs for the treatment or prevention of metabolic disorders caused by deregulated glucocorticoid signaling, such as insulin resistance, the metabolic syndrome, obesity and/or diabetes type II. Particular preferred embodiments of the invention pertain to antagonists or agonists of a miR of the conserved miR-379-410 cluster, particularly of miR-379. |
| 主权项 |
1. A method:
a) for the treatment or prevention of a glucocorticoid hormone driven metabolic dysfunction and/or a disease associated with elevated serum levels of triglycerides wherein said method comprises administering, to a patient in need of such treatment, an inhibitor of a micro RNA (miR), or of a target site of a miR, wherein the miR is selected from the group consisting of miR-379, miR-331-5p, miR-378*, miR-210, miR-152, miR-676*, mir-187, miR-1981, miR-203, miR-337-5p, miR-221, miR-222, miR-31*, miR-29b, miR-676, miR-34a, miR-383, miR-301a, miR-1274a, miR-134, miR-409-5p, miR-431, miR-382, miR-127 and miR-541, or b) for the treatment of Addison's disease or in increasing triglyceride serum levels in a patient, wherein said method comprises administering, to a patient in need of such treatment, an inhibitor of a miR, or of a target site of a miR, wherein the miR is selected from the group consisting of miR-719, miR-483, miR-669j, miR-146a, miR-1948, miR-342-3p, miR-24-2*, miR-132, miR-182, mir-677 and miR-18a. |
