| 发明名称 |
VACCINES COMPRISING LEISHMANIA POLYPEPTIDES FOR THE TREATMENT AND DIAGNOSIS OF LEISHMANIASIS |
| 摘要 |
Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise polypeptides comprising Leishmania antigens as well as polynucleotides encoding such polypeptides. |
| 申请公布号 |
US2016186158(A1) |
申请公布日期 |
2016.06.30 |
| 申请号 |
US201414780504 |
申请日期 |
2014.03.28 |
| 申请人 |
INFECTIOUS DISEASE RESEARCH INSTITUTE |
发明人 |
DUTHIE Malcolm;GUDERIAN Jeff;REED Steven G. |
| 分类号 |
C12N9/24;G01N33/569;C12N9/10;A61K39/008 |
主分类号 |
C12N9/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A fusion polypeptide comprising a Leishmania non-specific nucleoside hydrolase (NH) polypeptide, a Leishmania sterol 24-c-methyltransferase (SMT) polypeptide, and an immunogenic portion of a Leishmania polypeptide selected from the group consisting of a putative mitochondrial HSP70 (mtHSP70) polypeptide, a cysteine polypeptidease B (CpB) polypeptide, a histone H2BN (H2BN) polypeptide, an A2 polypeptide, ap21 antigen (p21) polypeptide, and a putative eukaryotic initiation factor 4a (LeiF) polypeptide. |
| 地址 |
Seattle WA US |
