发明名称 |
ONCOLYTIC HSV1 VECTOR AND METHODS OF USE |
摘要 |
Malignant tumors that are resistant to conventional therapies represent significant therapeutic challenges. An embodiment of the present invention provides a second generation oncolytic virus rQNestin34.5v2 with less toxicity that is more effective at selective killing target cells, such as tumor cells. In various embodiments presented herein, the oncolytic virus described herein is suitable for treatment of glioblastoma, as well as other cancers. |
申请公布号 |
WO2016179226(A1) |
申请公布日期 |
2016.11.10 |
申请号 |
WO2016US30681 |
申请日期 |
2016.05.04 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;NAKASHIMA, Hiroshi |
发明人 |
NAKASHIMA, Hiroshi;CHIOCCA, Ennio Antonio |
分类号 |
A61K48/00;C07H21/04;C12N15/00;C12Q1/70 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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