| 发明名称 |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF PERSISTENT INFECTIONS AND CANCER BY INHIBITING THE PROGRAMMED CELL DEATH 1 (PD-1) PATHWAY |
| 摘要 |
The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer. |
| 申请公布号 |
US2016362492(A1) |
申请公布日期 |
2016.12.15 |
| 申请号 |
US201615252133 |
申请日期 |
2016.08.30 |
| 申请人 |
Emory University ;Dana-Farber Cancer Institute, Inc. ;Brigham and Women's Hospital ;President and Fellows of Harvard College |
发明人 |
Freeman Gordon;Sharpe Arlene;Dorfman David M.;Ahmed Rafi;Barber Daniel;Wherry E. John |
| 分类号 |
C07K16/28;G01N33/574;C12N15/113;G01N33/50;A61K39/395;A61K45/06 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of increasing cytotoxic activity of anergic T cells in a subject having a lymphoproliferative cancer, comprising
administering to the subject having the lymphoproliferative cancer an effective amount of an agent that reduces the activity of a Programmed Cell Death (PD)-1 polypeptide, wherein the agent is an anti-PD-1 antibody, thereby increasing the cytotoxic activity of anergic T cells in the subject with the lymphoproliferative cancer, wherein the lymphoproliferative cancer is a Hodgkin's lymphoma. |
| 地址 |
Atlanta GA US |
