Use of RhoA in Cancer Diagnosis and Inhibitor Screening

摘要

Disclosed are a novel method of detecting cancer, a method of screening inhibitors and anticancer agents that target cancer-related molecules, RHOA polypeptide having mutation and a polynucleotide encoding the polypeptide as a therapeutic agent for cancer, and a method of detecting cancer using the polypeptide or polynucleotide. Also disclosed are a vector and a host cell comprising the polynucleotide, a method of screening therapeutic agents for cancer comprising the polypeptide and/or the polynucleotide, and a therapeutic agent for cancer comprising siRNA having a silencing effect on RHOA mutant.

主权项

1. A polypeptide having amino acid mutation(s) of
Arg at position 5, Gly at position 17, Leu at position 22, Val at position 38, Tyr at position 42, Glu at position 54, and/or Tyr at position 74,in the amino acid sequence set forth in SEQ ID NO: 1.