METHODS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR REDUCING METASTATIC DISSEMINATION

摘要

The present invention relates to methods and pharmaceutical compositions for preventing or reducing metastatic dissemination (i.e. reducing motility of cancer cells). In particular, the present invention relates to a method for preventing or reducing metastatic dissemination (i.e. reducing motility of cancer cells) in a subject suffering from a cancer comprising the steps consisting of i) determining the expression level of at least one biomarker selected from the group consisting of soluble CD95L and EMT promoting factors in a sample obtained from the subject, ii) comparing the expression level determined at step i) with a predetermined reference value and iii) administering the subject with a therapeutically effective amount of C16-ceramide or derivatives such as C16-sphingomyelin and C16-glycosphingolipids when the expression level determined at step i) is higher than the predetermined reference value.

主权项

1. A method for preventing or reducing metastatic dissemination in a subject suffering from a cancer comprising the steps of i) determining an expression level of at least one of I) soluble CD95L and II) one or more epithelial-to-mesenchymal transition (EMT) promoting factors in a sample obtained from the subject, ii) comparing the expression level determined at step i) with a predetermined reference value and iii) administering to subject a therapeutically effective amount of at least one compound selected from the group consisting of C16-ceramide, C16-sphingomyelin and C16-glycosphingolipid when the expression level determined at step i) is higher than the predetermined reference value.