| 发明名称 |
METHOD OF CONSTRUCTING MOUSE SUITABLE FOR THE TAKE, DIFFERENTIATION AND PROLIFERATION OF HETEROGENOUS CELLS, MOUSE CONSTRUCTED BY THIS METHOD AND USE OF THE MOUSE |
| 摘要 |
<p>The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor gamma -chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.</p> |
| 申请公布号 |
EP1338198(B1) |
申请公布日期 |
2007.11.28 |
| 申请号 |
EP20010978918 |
申请日期 |
2001.10.25 |
| 申请人 |
CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS |
发明人 |
ITO, MAMORU;KOBAYASHI, KIMIO;NAKAHATA, TATSUTOSHI;TSUJI, KOICHIRO;HABU, SONOKO;KOYANAGI, YOSHIO;YAMAMOTO, NAOKI;SUGAMURA, KAZUO;ANDO, KIYOSHI;NOMURA, TATSUJI |
| 分类号 |
A01K67/027;A61K39/00;A61K39/395;C12N5/08;C12N5/16;C12N15/12;G01N33/15;G01N33/50 |
主分类号 |
A01K67/027 |
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