发明名称 |
MiRNAs enhancing cell productivity |
摘要 |
The invention relates to a nucleic acid construct comprising at least two different regions, wherein the regions are selected of a first region encoding for at least one miRNA stimulating cellular production of a biomolecu!e in a cell, a second region encoding for at least one miRNA and/or miRNA-inhibitor suppressing cell death, and a third region encoding for at least one miRNA and/or miRNA-inhibitor regulating cell proliferation. The invention further relates to a cell comprising a respective nucleic acid construct and to a method for increasing the yield of a biomolecule produced by a cell cultured in vitro comprising at least two steps selected of stimulating cellular production of the biomolecule, reducing cell death, and regulating proliferation. |
申请公布号 |
AU2015250742(A1) |
申请公布日期 |
2016.11.17 |
申请号 |
AU20150250742 |
申请日期 |
2015.04.24 |
申请人 |
Hochschule Biberach |
发明人 |
Fischer, Simon;Handrick, Rene;Otte, Kerstin |
分类号 |
C12N15/11;C12N15/113;C12N15/67;C12N15/85 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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