| 发明名称 |
THERAPY REGIMEN AND METHODS TO SENSITIZE CANCER CELLS TREATED WITH EPIGENETIC THERAPY TO PARP INHIBITORS IN LUNG CANCER |
| 摘要 |
The presently disclosed subject matter provides methods to treat cancer cells using low doses of DNA demethylating agents and poly ADP ribose polymerase (PARP) inhibitors. Methods also are provided for sensitizing a cell to a PARP inhibitor. |
| 申请公布号 |
US2016367582(A1) |
申请公布日期 |
2016.12.22 |
| 申请号 |
US201615254738 |
申请日期 |
2016.09.01 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY ;UNIVERSITY OF MARYLAND, BALTIMORE |
发明人 |
RASSOOL Feyruz;BAYLIN Stephen;ROBERT Carine;Chowdhury Khadiza;Muvarak Nidal |
| 分类号 |
A61K31/706;A61K31/5025;A61K31/4184 |
主分类号 |
A61K31/706 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating lung cancer, the method comprising administering to a subject in need of treatment thereof an effective amount of a DNA demethylating agent and an effective amount of a poly ADP ribose polymerase (PARP) inhibitor. |
| 地址 |
Baltimore MD US |
