METHOD FOR PRODUCING AZONIASPIRONORTROPINE ESTERS

摘要

The present technology relates to an improved one-stage method for producing azoniaspironortropine esters such as trospium chloride by reacting an endonortropine compound with an organic dihalogen compound and an a-hydroxycarboxylic acid in the presence of a base and 1,1′carbonyldiimidazole or 1,1′thiocarbonyldiimidazole or thionyldiimidazole. The present technology also relates to an improved method for producing nortropan-3-one compounds or their hydrohalides (such as N-benzyltropanone hydrochloride) by reacting an amine and a protected dialdehyde with a basic aqueous solution of 1,3-acetone dicarboxylic acid.