发明名称 |
GLYCOPYRRONIUM FATTY ACID SALTS AND METHODS OF MAKING SAME |
摘要 |
Novel glycopyrronium fatty acid salts have been developed. Bi-phasic reaction conditions enable the desired counterion exchange reactions between glycopyrronium bromide and fatty acid salts of alkali metals and alkaline earth metals in methods to form glycopyrronium fatty acid salts. In preferred embodiments, an excess of the free fatty acid in the reaction mixture stabilizes the glycopyrronium fatty acid salt and reduces the formation of the impurity, Acid A. In some preferred embodiments, between 0.2 and 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. In another embodiment, approximately 1.2 molar equivalent of excess free fatty acid is added to the reaction mixture. |
申请公布号 |
WO2016204998(A1) |
申请公布日期 |
2016.12.22 |
申请号 |
WO2016US35967 |
申请日期 |
2016.06.06 |
申请人 |
QAAM PHARMACEUTICALS, LLC |
发明人 |
RICH, Steven A.;EISENREICH, Emerich;LIU, Xuejun Karl;MOBELE, Bingidimi Itute;PUPPALI, Satish Goud |
分类号 |
A61K9/42;A61K31/13;A61K31/185 |
主分类号 |
A61K9/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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