发明名称 HUMAN MONOCLONAL ANTIBODIES TO O8E
摘要 The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.
申请公布号 US2016168249(A1) 申请公布日期 2016.06.16
申请号 US201615048785 申请日期 2016.02.19
申请人 E.R. SQUIBB & SONS, L.L.C. 发明人 Korman Alan J.;Selby Mark J.;Lu Li-Sheng;Witte Alison J.;Huang Haichun
分类号 C07K16/28;A61K47/48;A61K51/10;C07K16/30 主分类号 C07K16/28
代理机构 代理人
主权项 1. An isolated human monoclonal antibody or an antigen-binding portion thereof, wherein the antibody: (a) binds to human O8E with a KD of 1×10−7 M or less; and (b) binds to a breast cell carcinoma tumor cell line.
地址 Princeton NJ US