| 发明名称 |
PROCESS FOR PREPARING AMPHIPHILIC PEPTIDE DERIVATIVES |
| 摘要 |
The present invention relates to novel derivatives of hydrophilic bioactive peptides which have been modified by introducing a lipophilic substituent through esterification of the free carboxylic group(s) of the peptide with an aliphatic alcohol. The present invention also refers to a simple, fast and effective process for the preparation of amphiphilic derivatives of peptides. It also refers to pharmaceutical compositions for the controlled release and delivery of these pharmacologically active peptides. |
| 申请公布号 |
US2016168224(A1) |
申请公布日期 |
2016.06.16 |
| 申请号 |
US201414904430 |
申请日期 |
2014.06.11 |
| 申请人 |
UNIVERSIDADE FEDERAL DE MINAS GERAIS - UFMG |
发明人 |
BRAGA Janaína Félix;FREZARD Frederic Jean Georges;SOUZA dos SANTOS Robson Augusto;SOUSA NETO Diógenes;de OLIVEIRA Mariana Flávia |
| 分类号 |
C07K14/575 |
主分类号 |
C07K14/575 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for preparation of amphiphilic derivatives of a peptide comprising an esterification reaction of the peptide with an aliphatic alcohol having melting point lower than 75° C. |
| 地址 |
Belo Horizonte BR |
