COMBINATION THERAPY FOR THE TREATMENT OF DIABETES AND CONDITIONS RELATED THERETO, AND FOR THE TREATMENT OF CONDITIONS AMELIORATED BY INCREASING BLOOD GLP-1 LEVEL

摘要

PROBLEM TO BE SOLVED: To provide a new approach in lowering a blood glucose level or in increasing a blood GLP-I level in a subject. SOLUTION: The present invention concerns combination of an amount of a GPR1 19 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-I level in a subject over that provided by the amount of the GPR1 19 agonist or the amount of the DPP-FV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions are ameliorated by increasing a blood GLP-I level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-I secretagogues. COPYRIGHT: (C)2008,JPO&INPIT