发明名称 CHEMICAL MOLECULES THAT INHIBIT THE SLICING MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICING ANOMALIES
摘要 A method of treating a disease selected from the group consisting of cancer, Duchenne muscular dystrophy, AIDS, and progeria, that includes administering to a patient in need thereof an effective quantity of at least one compound of formula (IV) or a pharmaceutically acceptable salt thereof.
申请公布号 US2016166519(A1) 申请公布日期 2016.06.16
申请号 US201514958602 申请日期 2015.12.03
申请人 CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE ;UNIVERSITE DE MONTPELLIER ;INSTITUT CURIE 发明人 TAZI Jamal;GRIERSON David;MAHUTEAU-BETZER Florence;ROUX Pierre
分类号 A61K31/166;A61K31/4409;A61K31/4725;A61K31/4439;A61K31/417;A61K31/4406;A61K31/4192 主分类号 A61K31/166
代理机构 代理人
主权项 1. A method of treating a disease selected from the group consisting of cancer, Duchenne muscular dystrophy, AIDS, and progeria, comprising: administering to a patient in need thereof an effective quantity of at least one compound of formula (IV) or a pharmaceutically acceptable salt thereof:where: X2 represents a nitrogen atom or a CR16 group; R16 is a hydrogen atom or a group selected from: X1 represents: a nitrogen atom,a NR11 group, ora CR10 group; R10 represents: a hydrogen atom,an NR11R12, oran OR11 group; R11 and R12 independently represent a hydrogen atom or a C1 to C3 alkyl group; R1 represents: a hydrogen atom,an NR11R12, oran OR12 group,with X1 representing a CH group when R1 represents an NR11R12 or an OR12 group;A represents: R4 represents: a hydrogen atom,a C1 to C3 alkyl group, ora C(═O)NR14R15 group,with R4 representing a hydrogen atom or a C1 to C3 alkyl group when R5 or R6 is not a hydrogen atom; R5 represents: a hydrogen atom,a C(═O)NR14R15 group, or with R5 representing a hydrogen atom when R4 or R6 is different than a hydrogen atom; R6 represents: a hydrogen atom,a C(═O)NR14R15 group, orgroup, with R6 representing a hydrogen atom when R5 is not a hydrogen atom or when R4 is not a hydrogen atom or a C1 to C3 alkyl group; R7 represents: a hydrogen atom,an NR11R12, oran OR12 group,with X2 representing a CH group when R7 represents an NR11R12 or an OR12 group; R14 and R15 independently represent: a hydrogen atom, ora linear or branched, substituted or unsubstituted C1 to C10 alkyl group, wherein one or more carbon atoms can be substituted by a nitrogen atom; and R21 and R22 independently represent a hydrogen atom or a methyl group;
地址 Paris FR