| 发明名称 |
APPARATUS FOR ANALYSING A MOLECULE |
| 摘要 |
An apparatus for analysing a molecule comprising:•a substrate;•at least one nanopore provided in the substrate;•first and second reservoirs separated by the substrate for respectively providing and receiving the molecule;•a controller to induce the molecule to move by from the first reservoir to the second reservoir via the nanopore;•at least one nanostructure arranged in the nanopore and/or around the nanopore on one side of the substrate for producing a localised electromagnetic field by plasmon resonance;•at least one coating provided in the substrate and/or on one side of the substrate for cooling the substrate and/or reflecting electromagnetic radiation incident thereon;;•a source of electromagnetic radiation arranged on the side of the substrate bearing the nanostructure(s) to induce plasmon resonance in each nanostructure and•a detector to detect signals produced by interaction of the electromagnetic field with the molecule as it passes through the nanopore. The apparatus is especially suitable for analysing biomolecules such as nucleic acids or proteins by Raman spectroscopy. |
| 申请公布号 |
US2016348163(A1) |
申请公布日期 |
2016.12.01 |
| 申请号 |
US201515114898 |
申请日期 |
2015.01.30 |
| 申请人 |
BASE4 INNOVATION LTD |
发明人 |
PODD Gareth;KULESHOVA Jekaterina;SOARES Bruno Flavio Nogueira de Sousa |
| 分类号 |
C12Q1/68;G01N21/65;G01N27/447;G01N33/487 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An apparatus for analysing a molecule, the apparatus comprising:
a substrate; at least one nanopore provided in the substrate; first and second reservoirs separated by the substrate for respectively providing and receiving the molecule; a controller to induce the molecule to move from the first reservoir to the second reservoir via the nanopore; at least one nanostructure arranged in the nanopore and/or around the nanopore on one side of the substrate for producing a localised electromagnetic field by plasmon resonance; at least one coating provided in the substrate and/or on one side of the substrate for cooling the substrate and/or reflecting electromagnetic radiation incident thereon; a source of electromagnetic radiation arranged on the side of the substrate bearing the nanostructure(s) to induce plasmon resonance in each nanostructure and a detector to detect signals produced by interaction of the electromagnetic field with the molecule as it passes through the nanopore. |
| 地址 |
Cambridge Cambridgeshire GB |
