摘要 |
FIELD: chemistry.SUBSTANCE: present invention relates to a novel compound of formula 33 and a method of producing a compound of formula LVII using compound of formula 33 as a starting compound. Compound of formula LVII possesses ability to inhibit JAK-kinase family, in particular JAK2 kinase. Compound LVII can be used for treating myeloproliferative disease, in treating idiopathic polycytemia, primary thrombocytopenia, myeloid fibrosis, proliferative diabetic retinopathy, cancer or eye disease. Compound of formula 33 corresponds to structural formulagiven below. Method of producing a compound of formula LVII involves reaction of 4-(2-pyrrolidin-1-yl-ethoxy)phenylamine with compound of formula 33. Method involves cleaning reaction mixture obtained at step of reacting a compound of formula 33 with 4-(2-pyrrolidin-1-yl-ethoxy)phenylamine, for separation of compound of formula XLV.EFFECT: obtaining a compound of formula LVII using compound of formula 33 as a starting compound.3 cl, 2 dwg, 3 tbl, 246 ex |