发明名称 ADHESIVE PREPARATION
摘要 <p>The invention provides an adhesive preparation comprising an elastic support and an adhesive layer laminated on at least one surface of the support. The elastic support is composed of a crimped woven fabric with stockinette stitch on both sides. The adhesive layer contains methyl salicylate in an amount of 10% by mass or more based on the total mass of the layer, and the water vapor transmission rate of the entire adhesive preparation measured at a temperature of 40°C and a relative humidity of 90% is 1 to 350 g/m<SUP>2</SUP>·24hr. When the application amount of the adhesive layer is set to 50 to 300 g/m<SUP>2</SUP> and the adhesive preparation is applied to the human skin for 8 hours such that the contact area is 280cm<SUP>2</SUP>, the average ± standard deviation of AUC<SUB>0-24</SUB> of the methyl salicylate in plasma is in the range of 3.0 to 60.0 ng·hr/mL, and the average ± standard deviation of AUC<SUB>0-24</SUB> of salicylic acid being a metabolite of the methyl salicylate in plasma is in the range of 5000 to 13000 ng·hr/mL.</p>
申请公布号 WO2008016077(A1) 申请公布日期 2008.02.07
申请号 WO2007JP65067 申请日期 2007.08.01
申请人 HISAMITSU PHARMACEUTICAL CO., INC.;TSURUDA, KIYOMI;YAMASOTO, SHINJI;SHOHO, KOUKI;NAKANISHI, MASARU 发明人 TSURUDA, KIYOMI;YAMASOTO, SHINJI;SHOHO, KOUKI;NAKANISHI, MASARU
分类号 A61K9/70;A61K31/045;A61K31/618;A61K47/10;A61K47/34;A61K47/46;A61P25/02;A61P29/00;A61P43/00 主分类号 A61K9/70
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