发明名称 |
FINE DISPERSION OF SPARINGLY SOLUBLE DRUG AND PROCESS FOR PRODUCING THE SAME |
摘要 |
An effective and simple process for producing a fine dispersion of a poorly soluble drug; and a fine sparingly-soluble-drug dispersion having excellent dispersion stability. In a first step, a poorly soluble drug is suspended in a liquid containing no deflocculant and the suspension is subjected to a high-pressure treatment with a high-pressure homogenizer. In a second step, a deflocculant is added to the dispersion obtained in the first step and this dispersion is subjected to a deagglomeration treatment such as a high-pressure treatment with a high-pressure homogenizer or an ultrasonic treatment. Thus, a fine dispersion of the poorly soluble drug is effectively and simply produced in which the size of the particles dispersed is on the order of nanometer. The fine sparingly-soluble-drug dispersion produced has excellent dispersion stability and the fine particles of the poorly soluble drug do not suffer aggregation/sedimentation even upon standing. Also provided is an excellent medicinal preparation reduced in the content of contaminants. It is obtained from the thus-produced fine dispersion of the poorly soluble drug. |
申请公布号 |
SI1731138(T1) |
申请公布日期 |
2016.06.30 |
申请号 |
SI20050032064 |
申请日期 |
2005.03.28 |
申请人 |
Toyama Chemical Co., Ltd. |
发明人 |
KUBO Yoshiko;YAMAKAWA Tetsumi;YAMASAKI Yasuomi |
分类号 |
A61K9/10;A61K31/343;A61K31/352;A61K31/4709;A61K31/497;A61K31/7048;A61K47/32;A61K47/34;A61K47/36 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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