发明名称 |
METHODS AND COMPOSITIONS FOR TREATING GASTROINTESTINAL STROMAL TUMOR(GIST) |
摘要 |
The invention features nucleic acid constructs encoding chimeric immunoreceptors (CIRs) that are useful for treating a KIT+ associated disease in patients. In general, the CIRs contain an extracellular domain (e.g., a KIT-ligand (KL) or stem cell factor (SCF)) which interacts with and destroys KIT+ tumor cells, a transmembrane domain, and a cytoplasmic domain for mediating T cell activation (e.g., CD3 zeta and/or the domain of CD28). The invention also features the use of the nucleic acid constructs and/or host cells expressing CIRs in the treatment of a KIT+ associated disease, in particular gastrointestinal stromal tumor (GIST). |
申请公布号 |
EP2951302(A4) |
申请公布日期 |
2016.07.20 |
申请号 |
EP20140746131 |
申请日期 |
2014.02.04 |
申请人 |
ROGER WILLIAMS MEDICAL CENTER |
发明人 |
KATZ, STEVEN, C.;JUNGHANS, RICHARD, P.;BAIS, ANTONY |
分类号 |
C12N15/00;C07H21/04 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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